[A clinico-pathological study of hepatocellular carcinoma patients with other primary malignancies]

In examining 293 patients with a hepatocellular carcinoma (HCC), 27 patients (9.2%) were found to have another primary malignancy located elsewhere. Of this number, fifteen were male and twelve were female, with ages that ranged from 53 to 81 years (mean 67.3 + 8.9 years). Twenty-four of these patients were found to have two other malignancies, where in 13 had both malignancies with a one year interval and other 11 after more than one year. The remains, three patients, had triple malignancies. These associated cancers included eight gastric cancers, four uterine, four colon cancers and other such cancers. The proportion of females with double cancers was higher than in those with only an HCC, although there were no difference in the HBsAg, age, past history of blood transfusion, the positive rate of familial malignancy, and the HCC between those with solely an HCC and those with other cancers as well. This suggests that the occurrence of an HCC concomitant with or followed by the development of another primary malignancy is not rare.