Related Experiment Video
Updated: Apr 18, 2026

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
6-(Bromomaleimido)hexanoic acid as a connector for the construction of multiple branched peptide platforms
Suhas Ramesh1, Prabhakar Cherkupally, Thavendran Govender
1Catalysis and Peptide Research Unit, School of Health Sciences and ‡School of Chemistry and Physics, University of KwaZulu-Natal , Durban 4001, South Africa.
Abstract:
We report on a novel and user-friendly platform based on a bromomaleimide moiety to obtain branched peptides. The platform is stable for all SPPS conditions. The bromomaleimide core was conjugated to n-copies of thiol-peptide in-solution to obtain two/four/eight-armed dendrimers. Using 'n' number of bromomaleimide analogues, 2(n) ligands were incorporated at both bromo and ene positions via a thioether bond. This method has the advantage of high conversion in a short time, thus enabling effortless purification and characterization processes.
Related Concept Videos
Peptide Bonds
Peptidoglycan Synthesis

