The contribution of strains and hosts to outcomes in Clostridium difficile infection

Acquisition of Clostridium difficile spores can be followed by a spectrum of clinical outcomes ranging from asymptomatic transit through the bowel to severe colitis and death. This clinical variability is a product of bacterial virulence and host susceptibility to the pathogen. It is important to identify patients at high risk of poor outcome so that increased monitoring and optimal treatment strategies can be instigated. This article discusses the evidence linking strain type to clinical outcome, including the importance of toxin and nontoxin virulence factors. It reviews host factors and their relationship with C difficile infection susceptibility, recurrence, and mortality.