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Updated: Apr 18, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
[Some thoughts on the links between LC-MS/MS and therapeutic drug monitoring]
1Laboratoire de toxicologie, Faculté de pharmacie, Université de Limoges, France ; Service de pharmacologie, toxicologie et pharmacovigilance, CHU de Limoges, France ; Inserm UMR 850, Université de Limoges, France.
Abstract:
Therapeutic drug monitoring can be defined as a multiple step activity involving: (i) the measurement of a drug; (ii) the interpretation of the concentration by taking into account the concentration-effect relationship; (iii) the individual dose adjustment. For over 15 years pharmacology-toxicology departments have implemented liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) on a daily basis. This article discusses the current position of this technology in TDM routine activity.
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