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Acridone-based antitumor agents: a mini-review.

Wesam S Alwan, Anand A Mahajan1, Rajesh A Rane

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The acridone scaffold shows significant potential for drug discovery, particularly in developing new anti-cancer agents to combat multi-drug resistance. This review details acridone synthesis and antitumor activities from 2000-2014.

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Area of Science:

  • Medicinal Chemistry
  • Organic Chemistry
  • Pharmacology

Background:

  • The tricyclic acridone ring system is a key scaffold in medicinal chemistry due to its significant biological activities.
  • Acridone derivatives exhibit potential as antibacterial, antimalarial, antiviral, and anti-neoplastic agents.
  • The ability of acridone to reverse multi-drug resistance makes it a promising candidate for cancer therapy.

Purpose of the Study:

  • To review the synthesis of acridone derivatives.
  • To summarize the antitumor activities of acridone compounds.
  • To highlight the potential of acridone scaffolds in overcoming multi-drug resistance in cancer.

Main Methods:

  • Literature review of scientific publications from 2000 to 2014.
  • Analysis of synthetic routes for various acridone derivatives.
  • Compilation and assessment of reported antitumor activities and mechanisms.

Main Results:

  • Numerous acridone derivatives have been synthesized with diverse structural modifications.
  • Many acridone compounds demonstrate significant in vitro and in vivo antitumor efficacy.
  • Acridone derivatives show promise in overcoming multi-drug resistance mechanisms in cancer cells.

Conclusions:

  • The acridone scaffold is a versatile and valuable platform for the development of novel anticancer drugs.
  • Further research into acridone derivatives is warranted to optimize their therapeutic potential and clinical application.
  • Acridone-based compounds represent a promising strategy for combating multi-drug resistant cancers.