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Updated: Apr 18, 2026

Prion Safety Laboratory Swipe Test
Published on: February 14, 2025
Prion degradation pathways: Potential for therapeutic intervention
Rob Goold1, Chris McKinnon1, Sarah J Tabrizi1
1Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, United Kingdom.
Abstract:
Prion diseases are fatal neurodegenerative disorders. Pathology is closely linked to the misfolding of native cellular PrP(C) into the disease-associated form PrP(Sc) that accumulates in the brain as disease progresses. Although treatments have yet to be developed, strategies aimed at stimulating the degradation of PrP(Sc) have shown efficacy in experimental models of prion disease. Here, we describe the cellular pathways that mediate PrP(Sc) degradation and review possible targets for therapeutic intervention. This article is part of a Special Issue entitled 'Neuronal Protein'.
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