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Related Concept Videos

Types of Step-Growth Polymers: Polyesters01:20

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The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the...
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Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
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Trypsin-inspired poly(urethane-urea)s based on poly-lysine oligomer segment.

Zhenqian Gu1, Fangjie Wang, Haoxiang Lu

  • 1a School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites , Shanghai Jiao Tong University , Shanghai 200240 , P.R. China.

Journal of Biomaterials Science. Polymer Edition
|January 14, 2015
PubMed
Summary

New biodegradable poly(urethane-urea)s incorporating poly-lysine oligomers show enhanced degradation in the presence of trypsin. These materials exhibit good biocompatibility and improved thermal stability and hydrophilicity, making them promising for biomedical applications.

Keywords:
degradationlysinepoly(urethane-urea)strypsin

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Materials Engineering

Background:

  • Biodegradable polymers are crucial for biomedical applications, reducing long-term complications.
  • Poly(urethane-urea)s offer versatile properties but often lack controlled degradation.
  • Incorporating peptide-based segments can enhance biodegradability and biocompatibility.

Purpose of the Study:

  • To synthesize and characterize novel biodegradable poly(urethane-urea)s using poly-lysine oligomers as soft segments.
  • To investigate the in vitro degradation behavior and biocompatibility of these new materials.
  • To evaluate the effect of poly-lysine content on material properties like degradability, thermostability, and hydrophilicity.

Main Methods:

  • Synthesis of poly(urethane-urea)s with varying poly-lysine oligomer content.
  • In vitro degradation studies using simulated pancreatic juice with trypsin and buffer solutions.
  • Characterization via (1)H NMR and mass loss measurements.
  • Cell viability assays using endothelial cells.

Main Results:

  • Poly(urethane-urea)s demonstrated effective cleavage of peptide bonds in the presence of trypsin, indicating enzymatic degradability.
  • Degradation was significantly enhanced by the inclusion of poly-lysine oligomers in the polymer backbone.
  • Cell viability tests confirmed good biocompatibility with endothelial cells.
  • Thermostability and hydrophilicity increased with higher poly-lysine oligomer content.

Conclusions:

  • The novel poly(urethane-urea)s are biodegradable, particularly in enzymatic environments, due to the poly-lysine segments.
  • These materials exhibit excellent biocompatibility and tunable thermal and hydrophilic properties.
  • The incorporation of poly-lysine oligomers presents a viable strategy for developing advanced biodegradable poly(urethane-urea)s for biomedical use.