Recent advances in bioprinting and applications for biosensing

Area of Science:

• Biotechnology
• Materials Science
• Sensor Technology

Background:

• Future biosensing demands include real-time monitoring, feedback integration, toxin detection, and advanced diagnostics.
• Achieving these requires biosensors with enhanced sensitivity, specificity, throughput, and multiplexing capabilities.
• Current biofabrication techniques are crucial for developing sensors with high spatial sensitivity.

Purpose of the Study:

• To review recent advances in biofabrication techniques for cutting-edge biosensor development.
• To highlight the role of bioprinting in biosensor fabrication and scaling.
• To explore the potential of 3D bioprinting for creating novel biosensor platforms.

Main Methods:

• Review of recent literature on biofabrication techniques, focusing on bioprinting methods.
• Analysis of specific bioprinting techniques: microcontact printing, inkjet printing, and laser direct-write.
• Exploration of 3D bioprinting for creating biosensors with encapsulated live cells.

Main Results:

• Bioprinting techniques show promise for fabricating biosensors with improved performance.
• Successful application of these techniques in recent biosensor development.
• Potential for multiplexing analytes or cell types within a single biosensor.
• 3D bioprinting offers new possibilities for biosensors in 3D microenvironments.

Conclusions:

• Biofabrication advances, especially bioprinting, are critical for meeting future biosensing requirements.
• These techniques can lead to higher performance biosensors, including multiplexed and 3D-cell-based devices.
• Expanded utility and availability of biosensors will impact interdisciplinary fields and clinical applications.