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Updated: Apr 18, 2026
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Mild and selective Et2Zn-catalyzed reduction of tertiary amides under hydrosilylation conditions
Oleksandr O Kovalenko1, Alexey Volkov, Hans Adolfsson
1Department of Organic Chemistry, Arrhenius Laboratory Stockholm University , SE-106 91, Stockholm, Sweden.
Abstract:
Diethylzinc (Et2Zn) can be used as an efficient and chemoselective catalyst for the reduction of tertiary amides under mild reaction conditions employing cost-effective polymeric silane (PMHS) as the hydride source. Crucial for the catalytic activity was the addition of a substoichiometric amount of lithium chloride to the reaction mixture. A series of amides containing different additional functional groups were reduced to their corresponding amines, and the products were isolated in good-to-excellent yields.
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