Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal, label-free, high-resolution imaging of glioblastoma spheroid response to therapy: a translational tool for preclinical evaluation of chemotherapy, radiation, and immunotherapy.

Optica·2026
Same author

Neurometabolic substrate utilization governs oxidative phosphorylation conductance in cortex and hippocampus.

Journal of neurophysiology·2026
Same author

Disrupting Akt-Wnt/β-catenin signaling suppresses glioblastoma stem cell growth and tumor progression in immunocompetent mice.

Journal of neuro-oncology·2026
Same author

Illuminating the Interface of Blocc Chemistry and Data Science: Maximizing Function with ML-Guided Discovery and a Digital Molecule Maker.

Journal of chemical education·2026
Same author

Illuminating the Interface of Blocc Chemistry and Data Science: An Introduction to K‑Nearest Neighbor Analysis and K‑Medoids Clustering.

Journal of chemical education·2026
Same author

Finite element analysis of a neural implant for cytostatic hypothermia and a novel heat management system.

Journal of neural engineering·2025
Same journal

Bithiophene Scaffold for PET Imaging and Photosensitization as a Novel Theranostic Platform Targeting Amyloid-β Aggregates.

ACS chemical neuroscience·2026
Same journal

Low Agonism and Balanced Pathway Modulation Distinguish an M1 Muscarinic Receptor Positive Allosteric Modulator Lacking Cholinergic Adverse Effects.

ACS chemical neuroscience·2026
Same journal

Imaging Synaptic Vesicle Protein SV2C with <sup>18</sup>F-UCB-F: An In Vitro Autoradiography and In Vivo NHP PET Study.

ACS chemical neuroscience·2026
Same journal

UBOX5 Modulates the Cognitive Dysfunction by Degrading HSP70 Protein in Sleep-Deprived Mice.

ACS chemical neuroscience·2026
Same journal

Involvement of Raphe Nuclei in Depressive-like Behaviors and Short-Term Memory in an Animal Model of Parkinson's Disease.

ACS chemical neuroscience·2026
Same journal

Comprehensive Evaluation of Indazole-Based Synthetic Cannabinoid Receptor Agonists with Aliphatic Tail Groups: In Vitro Activities, Metabolic Stability, and In Vivo Pharmacokinetics.

ACS chemical neuroscience·2026
See all related articles

Related Experiment Video

Updated: Apr 18, 2026

Chronic Cranial Window Technique for Repeated Cortical Recordings During Anesthesia in Pigs
07:19

Chronic Cranial Window Technique for Repeated Cortical Recordings During Anesthesia in Pigs

Published on: June 6, 2025

680

Intracortical recording interfaces: current challenges to chronic recording function.

Bhagya Gunasekera1, Tarun Saxena, Ravi Bellamkonda

  • 1Regenerative Bioscience Center, ADS Complex, The University of Georgia , Athens, Georgia 30602-2771, United States.

ACS Chemical Neuroscience
|January 15, 2015
PubMed
Summary
This summary is machine-generated.

Brain Computer Interfaces (BCIs) use intracortical recording interfaces (IRIs) to help paralyzed individuals control devices. This review examines IRI design, function, and failure, aiming for improved long-term BCI use.

Keywords:
Brain computer interfacesforeign body responseintracortical neural interfaces

More Related Videos

Chronic Transcranial Electrical Stimulation and Intracortical Recording in Rats
10:51

Chronic Transcranial Electrical Stimulation and Intracortical Recording in Rats

Published on: May 11, 2018

9.4K
Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals
08:26

Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals

Published on: February 24, 2012

48.5K

Related Experiment Videos

Last Updated: Apr 18, 2026

Chronic Cranial Window Technique for Repeated Cortical Recordings During Anesthesia in Pigs
07:19

Chronic Cranial Window Technique for Repeated Cortical Recordings During Anesthesia in Pigs

Published on: June 6, 2025

680
Chronic Transcranial Electrical Stimulation and Intracortical Recording in Rats
10:51

Chronic Transcranial Electrical Stimulation and Intracortical Recording in Rats

Published on: May 11, 2018

9.4K
Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals
08:26

Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals

Published on: February 24, 2012

48.5K

Area of Science:

  • Neuroscience and Biomedical Engineering
  • Focuses on Brain Computer Interfaces (BCIs) and neural recording technologies.

Background:

  • BCIs offer mobility restoration for individuals with paralysis.
  • Intracortical recording interfaces (IRIs) are crucial for translating neural signals.
  • Acute IRI failure compromises long-term BCI functionality.

Purpose of the Study:

  • To review current IRI designs and functions.
  • To explore cellular and molecular causes of acute IRI failure.
  • To present recent IRI design advancements and future directions.

Main Methods:

  • Review of existing literature on intracortical recording interfaces.
  • Analysis of factors contributing to acute recording failure.
  • Discussion of technological innovations in IRI design.

Main Results:

  • Recent innovations have improved BCI performance.
  • Acute IRI failure is a significant barrier to chronic BCI use.
  • Understanding cellular/molecular events is key to overcoming failure.

Conclusions:

  • Further research into IRI design is needed for chronic functionality.
  • Addressing acute failure mechanisms will enhance BCI efficacy.
  • Future IRIs aim for sustained, high-fidelity neural signal recording.