Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cross-bridge Cycle01:26

Cross-bridge Cycle

125.8K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
125.8K
Amyloid Fibrils03:03

Amyloid Fibrils

13.2K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
13.2K
Amyloid Fibrils03:03

Amyloid Fibrils

7.0K
7.0K
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

3
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of...
3
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

4
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
4
Neural Regulation01:37

Neural Regulation

45.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
45.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nuclear and genome dynamics underlying DNA double-strand break repair.

Nature reviews. Molecular cell biology·2025
Same author

Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment.

NAR cancer·2025
Same author

Nucleolar Pol II interactome reveals TBPL1, PAF1, and Pol I at intergenic rDNA drive rRNA biogenesis.

Nature communications·2024
Same author

Protocol for machine-learning-based 3D image analysis of nuclear envelope tubules in cultured cells.

STAR protocols·2024
Same author

DNA double-strand break-capturing nuclear envelope tubules drive DNA repair.

Nature structural & molecular biology·2024
Same author

SARS-CoV-2 targets ribosomal RNA biogenesis.

Cell reports·2024

Related Experiment Video

Updated: Apr 18, 2026

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
08:53

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells

Published on: May 16, 2017

9.3K

R-loops highlight the nucleus in ALS.

Jayesh S Salvi1, Karim Mekhail

  • 1a Department of Laboratory Medicine and Pathobiology; Faculty of Medicine ; University of Toronto ; Toronto , ON Canada.

Nucleus (Austin, Tex.)
|January 15, 2015
PubMed
Summary
This summary is machine-generated.

RNA-DNA hybrids are crucial in understanding amyotrophic lateral sclerosis (ALS), a neurodegenerative disease. These hybrids highlight the nucleus's role and may link various ALS genes, offering insights into the disease.

Keywords:
Amyotrophic lateral sclerosis (ALS)Ataxin2C9ORF72FUSR-loopRNA-DNA hybridSOD1SenataxinTDP43genome instabilitystress granules

More Related Videos

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
08:59

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

3.3K
Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
07:14

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Published on: February 25, 2022

6.7K

Related Experiment Videos

Last Updated: Apr 18, 2026

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
08:53

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells

Published on: May 16, 2017

9.3K
Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
08:59

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

3.3K
Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
07:14

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Published on: February 25, 2022

6.7K

Area of Science:

  • Neurobiology
  • Genetics
  • Molecular Biology

Background:

  • Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease.
  • ALS is linked to genetic mutations affecting cytoplasmic RNA metabolism.
  • Emerging research connects ALS-related factors to RNA-DNA hybrid (R-loop) regulation.

Purpose of the Study:

  • To investigate the role of RNA-DNA hybrid regulation in ALS.
  • To explore the nucleus's involvement in ALS pathogenesis.
  • To propose a molecular mechanism linking different ALS genes via RNA-DNA hybrids.

Main Methods:

  • Review of genetic models and recent studies on ALS-linked factors.
  • Analysis of RNA-DNA hybrid regulatory processes.
  • Examination of the nucleus's function in ALS.

Main Results:

  • RNA-DNA hybrid regulation is implicated in ALS.
  • The nucleus plays a significant role in ALS.
  • RNA-DNA hybrids may serve as a unifying molecular link between various ALS-associated genes.

Conclusions:

  • RNA-DNA hybrids are pivotal in understanding ALS.
  • Further research into RNA-DNA hybrids could unlock new therapeutic strategies for ALS and other human diseases.