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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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[Clinicopathological correlations at the vitreoretinal interface].

R G Schumann1, A Gandorfer, A Kampik

  • 1Vitreoretinale Pathologie und Elektronenmikroskopie, Augenklinik der Ludwig-Maximilians-Universität, Mathildenstr. 8, 80336, München, Deutschland, ricarda.schumann@med.uni-muenchen.de.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|January 16, 2015
PubMed
Summary
This summary is machine-generated.

Understanding vitreoretinal interface (VRI) pathology is key for diagnosing and treating vitreal maculopathy. Successful treatment involves removing vitreomacular adhesions and internal limiting membrane (ILM) in cases of epiretinal proliferation.

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Vitreoretinal Interface Pathology

Context:

  • Clinicopathological studies of the vitreoretinal interface (VRI) are crucial for understanding vitreal maculopathy.
  • These studies aid in differential diagnoses and the development of novel treatment strategies.

Purpose:

  • To provide a comprehensive overview of clinicopathological correlations of the vitreoretinal interface (VRI).

Summary:

  • Age-related vitreous changes and persistent vitreomacular adhesions promote cellular migration and proliferation on the internal limiting membrane (ILM).
  • Vitreoschisis and anomalous posterior vitreous detachment contribute to epiretinal membrane formation, involving glial cells, hyalocytes, and myofibroblasts.
  • Successful treatment requires removing vitreomacular adhesions and vitreous cortex collagen fibrils; ILM removal is essential for preventing recurrence in epiretinal proliferation cases.

Impact:

  • Informs pathogenesis of vitreal maculopathy.
  • Guides development of new diagnostic and therapeutic approaches.
  • Highlights the need for improved detection technologies for epiretinal cell proliferation.