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Appendectomy: a risk factor for colectomy in patients with Clostridium difficile
Felix A Yong1, Anthony M Alvarado1, Huaping Wang2
1Department of Surgery, University of Illinois-Peoria, 624 NE Glen Oak Ave. Peoria IL 61603-3135, USA.
American Journal of Surgery
|January 16, 2015
Summary
Appendectomy may increase the risk of severe Clostridium difficile infection. Patients without an appendix had a higher colectomy rate, indicating increased disease severity, suggesting appendectomy is a risk factor.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Surgical Outcomes
Background:
- The appendix serves as a reservoir for intestinal microbiota.
- Its role in mitigating severe Clostridium difficile infection (CDI) is under investigation.
Purpose of the Study:
- To investigate the association between appendectomy and the severity of Clostridium difficile infection.
- To determine if appendectomy is a risk factor for fulminant CDI.
Main Methods:
- Retrospective analysis of 507 patients with CDI from 2007-2011.
- Comparison of infection outcomes and appendectomy history.
- Statistical analysis using chi-square and multivariate logistic regression.
Main Results:
- Patients with a history of appendectomy had a higher colectomy rate (10.9%) compared to those with an intact appendix (5.2%).
- Appendectomy was associated with increased disease severity, indicated by a higher colectomy rate (P = .03).
- Multivariate regression adjusted for age and sex confirmed the association (P = .05).
Conclusions:
- Appendectomy may be a significant risk factor for increased severity of Clostridium difficile infection.
- The underlying mechanisms require further investigation.
- Additional research is warranted to elucidate the relationship between appendectomy and CDI outcomes.
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