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Updated: Apr 18, 2026
A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
C-C coupling of ketones with methanol catalyzed by a N-heterocyclic carbene-phosphine iridium complex
Xu Quan1, Sutthichat Kerdphon, Pher G Andersson
1Department of Organic Chemistry, Stockholm University, The Arrhenius laboratory, 10691 Stockholm (Sweden).
Abstract:
An N-heterocyclic carbene-phosphine iridium complex system was found to be a very efficient catalyst for the methylation of ketone via a hydrogen transfer reaction. Mild conditions together with low catalyst loading (1 mol %) were used for a tandem process which involves the dehydrogenation of methanol, C=C bond formation with a ketone, and hydrogenation of the new generated double bond by iridium hydride to give the alkylated product. Using this iridium catalyst system, a number of branched ketones were synthesized with good to excellent conversions and yields.
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