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Human tumor necrosis factor increases the resistance against Listeria infection in mice
1Department of Internal Medicine, Tomakomai City Hospital, Japan.
Medical Microbiology and Immunology
|January 1, 1989
Abstract:
The resistance in mice against Listeria infection was augmented by treatment with recombinant human tumor necrosis factor (TNF). To elucidate this phenomenon, we examined the effect of TNF on macrophage activation. TNF-treated macrophages had listericidal activity in vitro and superoxide anion production. In addition, macrophage migration was inhibited in the presence of TNF. Therefore, activation of macrophages by TNF was similar to activation by macrophage-activating factor or macrophage-migration-inhibitory factor.