Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccine Production01:23

Vaccine Production

108
Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
108

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In-bedroom renewed air as anti-inflammatory adjuvant therapy in cancer survivors: protocol for the randomised, placebo-controlled BREATHS N-of-1 trial series.

BMJ open·2026
Same author

Post-Synthesis Modulation of the Physicochemical Properties of Green-Synthesized Iron Oxide Nanoparticles with Tween 80 to Enhance Their Antibacterial Activity and Biocompatibility.

Pharmaceutics·2025
Same author

Twenty years of genome-wide association studies: Health translation challenges and AI opportunities.

European journal of human genetics : EJHG·2025
Same author

Comparative Analysis of a Rapid Quantitative Immunoassay to the Reference Methodology for the Measurement of Blood Vitamin D Levels.

Methods and protocols·2025
Same author

Antiviral Activity of Rhamnolipids Nano-Micelles Against Rhinoviruses-In Silico Docking, Molecular Dynamic Analysis and In-Vitro Studies.

Current issues in molecular biology·2025
Same author

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19.

Nature communications·2025
See all related articles

Related Experiment Video

Updated: Apr 18, 2026

Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

23.0K

Developing a vaccine for human rhinoviruses.

Gary R McLean1

  • 1Cellular and Molecular Immunology Research Centre, London Metropolitan University, London, N7 8DB, UK.

Journal of Vaccines & Immunization
|January 17, 2015
PubMed
Summary
This summary is machine-generated.

Rhinoviruses cause common colds and worsen chronic airway diseases. Current vaccine strategies fail due to numerous serotypes, highlighting the need for new approaches to combat these common respiratory pathogens.

Keywords:
chronic airway diseaseshuman pathogensimmunitymouse modelrhinovirusvaccine

More Related Videos

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.5K
Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
12:09

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

Published on: May 2, 2011

43.6K

Related Experiment Videos

Last Updated: Apr 18, 2026

Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

23.0K
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.5K
Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
12:09

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

Published on: May 2, 2011

43.6K

Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • Rhinoviruses (RVs) are frequent causes of upper respiratory tract infections, commonly known as the common cold.
  • RVs are significant triggers for acute exacerbations in chronic airway diseases, posing life-threatening risks.
  • The economic impact of RV infections includes lost productivity due to work and school absenteeism.

Purpose of the Study:

  • To review past and current strategies for developing a vaccine against rhinoviruses.
  • To address the challenges posed by the vast number of RV serotypes and the lack of cross-serotype immunity.
  • To explore potential avenues for effective rhinoviral vaccine development.

Main Methods:

  • Literature review of existing rhinoviral vaccine research.
  • Analysis of historical vaccine development approaches.
  • Examination of current research trends and challenges in rhinoviral vaccine design.

Main Results:

  • Vaccine development for rhinoviruses has been historically challenging.
  • The large number of RV serotypes impedes the generation of broad, cross-serotype protection.
  • Existing vaccine strategies have not yet yielded successful outcomes.

Conclusions:

  • Effective antiviral therapies for rhinoviruses are currently unavailable.
  • Developing a universal rhinoviral vaccine remains a significant unmet medical need.
  • Further research into novel vaccine platforms and immunogenic targets is crucial for future success.