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A glance at methods for cleft palate repair.
Sima Tavakolinejad1, Alireza Ebrahimzadeh Bidskan1, Hami Ashraf2
1Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
Iranian Red Crescent Medical Journal
|January 17, 2015
Summary
Tissue engineering offers promising new approaches for cleft palate reconstruction, addressing a common birth defect. Stem cells and growth factors are crucial for advancing these innovative treatments.
Area of Science:
- Craniofacial Surgery
- Regenerative Medicine
- Pediatric Plastic Surgery
Background:
- Cleft palate is a frequent congenital anomaly, posing significant challenges in pediatric plastic surgery.
- Current treatment protocols lack standardization, often necessitating multiple surgeries with suboptimal outcomes.
Purpose of the Study:
- To provide a comprehensive overview of cleft palate development and therapeutic strategies.
- To explore novel aspects and future advancements in cleft palate treatment, including tissue engineering.
Main Methods:
- Literature search using terms like 'cleft palate repair', 'stem cells', 'tissue engineering', and 'bone tissue engineering'.
- Inclusion criteria focused on articles defining therapeutic strategies or assessing new techniques for palatal cleft closure.
Main Results:
- Summarized key aspects of cleft palate development and associated genes.
- Highlighted current therapeutic strategies and emerging novel approaches.
- Integrated findings with recent clinical experiences for practical insights.
Conclusions:
- Tissue engineering presents a promising frontier for cleft palate reconstruction.
- Stem cells and growth factors are identified as pivotal components in advancing this field.
