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TAM receptor signaling in immune homeostasis

Carla V Rothlin1, Eugenio A Carrera-Silva, Lidia Bosurgi

  • 1Department of Immunobiology and.

Annual Review of Immunology
|January 17, 2015
PubMed

Insights

The TAM receptor tyrosine kinases (RTKs) and their ligands are crucial for resolving inflammation and maintaining immune homeostasis. Dysfunctional TAM signaling is linked to chronic inflammatory, autoimmune, infectious diseases, and cancer.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • TAM receptor tyrosine kinases (RTKs), including TYRO3, AXL, and MERTK, are key regulators of immune responses.
  • These RTKs, along with their ligands GAS6 and PROS1, are vital for the resolution of inflammation.
  • Deficiencies in TAM signaling pathways are implicated in chronic inflammatory and autoimmune diseases.

Purpose of the Study:

  • To review the discovery and functional importance of TAM RTKs and their ligands.
  • To highlight the role of TAM signaling in immune homeostasis and disease.
  • To discuss recent findings on TAMs in infectious diseases and cancer.

Main Methods:

  • Literature review of key studies on TAM receptor tyrosine kinases and their ligands.
  • Analysis of research on the physiological and pathological roles of TAM signaling.
  • Synthesis of findings related to innate immunity, efferocytosis, and vascular integrity.

Main Results:

  • TAM signaling is essential for resolving inflammation and maintaining immune homeostasis.
  • Key processes regulated by TAMs include innate immune response suppression, apoptotic cell phagocytosis, and vascular integrity restoration.
  • TAM signaling also plays a role in infectious diseases and cancer.

Conclusions:

  • TAM RTKs and their ligands are critical for immune regulation in both health and disease.
  • Understanding TAM signaling provides insights into potential therapeutic strategies for inflammatory and autoimmune conditions.
  • Further research into TAMs' roles in infectious diseases and cancer is warranted.
Keywords:
AXLGAS6MERTKPROS1TYRO3

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