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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Related Experiment Video

Updated: Apr 18, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

PTENtiating autoimmunity through Treg cell deregulation

John P Ray¹, Joe Craft²

¹Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

Nature Immunology

|January 17, 2015

Summary

No abstract available in PubMed .

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