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Related Experiment Video

Updated: Apr 18, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
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A modular DNA origami-based enzyme cascade nanoreactor.

Veikko Linko1, Marika Eerikäinen, Mauri A Kostiainen

  • 1Biohybrid Materials, Department of Biotechnology and Chemical Technology, Aalto University, FI-00076 Aalto, Finland. mauri.kostiainen@aalto.fi.

Chemical Communications (Cambridge, England)
|January 17, 2015
PubMed
Summary
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Researchers developed a nanoscale reactor using DNA origami. This modular system efficiently combines enzymes for cascade reactions, showing potential as a diagnostic tool.

Area of Science:

  • Nanotechnology
  • Biochemistry
  • Molecular Engineering

Background:

  • DNA origami enables precise nanoscale construction.
  • Enzyme cascade reactions are crucial for various biochemical processes.
  • Developing controlled nanoscale reaction environments is challenging.

Purpose of the Study:

  • To create a tuneable nanoscale reactor using DNA origami.
  • To demonstrate controllable assembly of enzyme-functionalized origami units.
  • To achieve efficient enzyme cascade reactions within the nanoscale reactor.

Main Methods:

  • Assembly of tubular DNA origami units.
  • Functionalization of DNA origami with glucose oxidase (GOx) and horseradish peroxidase (HRP).
  • Controllable combination of separate origami units to initiate enzyme cascade reactions.

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Related Experiment Videos

Last Updated: Apr 18, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
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Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

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Design and Synthesis of a Reconfigurable DNA Accordion Rack
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Design and Synthesis of a Reconfigurable DNA Accordion Rack

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Designing a Bio-responsive Robot from DNA Origami
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Main Results:

  • Successful assembly of a nanoscale reactor from DNA origami units.
  • Demonstration of efficient glucose oxidase/horseradish peroxidase (GOx/HRP) enzyme cascade reaction.
  • Spatial addressability and tuneability of the reactor components.

Conclusions:

  • The DNA origami-based nanoscale reactor enables efficient enzyme cascade reactions.
  • The modularity of the system allows for complex reaction setups.
  • The reactor shows promise as a nanoscale diagnostic tool.