Biphasic recovery in n-hexane polyneuropathy. A clinical and electrophysiological study

We studied the course of recovery in n-hexane polyneuropathy in 4 patients by quantitatively assessing clinical and electrophysiological features. The electrophysiological study included measures of motor conduction of the median, ulnar, tibial and peroneal nerves and sensory conduction of the median, ulnar and sural nerves. After cessation of exposure, there was an initial worsening in muscle strength, sensory deficit and nerve conduction for up to 2-5 months. This deterioration was more severe and prolonged in the lower limbs than in the upper limbs. The period of deterioration was followed by a slow recovery studied for 1 year.