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Subcutaneous panniculitis-like T-cell lymphoma with bone marrow involvement
Noah A Brown1, Charles W Ross1, Johann E Gudjonsson2
1From the Departments of Pathology.
American Journal of Clinical Pathology
|January 18, 2015
Summary
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) can rarely affect the bone marrow. Bone marrow involvement mirrors skin findings, showing cytotoxic T cells surrounding fat cells.
Area of Science:
- Hematology
- Oncology
- Dermatopathology
Background:
- Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cytotoxic T-cell lymphoma.
- Bone marrow involvement is an uncommon but serious complication of SPTCL.
Observation:
- A case of SPTCL with confirmed bone marrow infiltration is presented.
- Morphological analysis revealed lymphohistiocytic aggregates with atypical cytotoxic T cells rimming adipocytes and karyorrhexis in the bone marrow.
Findings:
- Immunohistochemical studies showed T cells expressing CD2, CD3, CD7, CD8, and granzyme B, with diminished CD5 expression.
- These findings were identical to the concurrent SPTCL in the skin and subcutaneous tissue.
Implications:
- This case highlights the importance of considering bone marrow evaluation in SPTCL.
- Similar morphologic and immunophenotypic features in bone marrow and subcutaneous tissue aid in diagnosis.
- Understanding SPTCL bone marrow involvement is crucial for accurate staging and treatment planning.
Keywords:
Atypical lymphocytic lobular panniculitisBone marrow involvementHemophagocytic syndromeLupus panniculitisSubcutaneous panniculitis-like T-cell lymphomaMore Related Videos
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