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Suppression of antigen presentation by IL-10

Sharad K Mittal1, Paul A Roche1

  • 1Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Current Opinion in Immunology
|January 20, 2015
PubMed

Regulated antigen presentation to immune cells determines the effectiveness of an immune response. IL-10 is an immunosuppressive cytokine that regulates immune responses by inhibiting the ability of APCs to present antigens to T cells in a variety of ways. The mechanisms of IL-10-mediated immunosuppression include interference in TLR-mediated or IFNγ-mediated dendritic cell (DC) and macrophage activation as well as direct induction of genes that suppress APC function. In this review we will discuss current studies exploring the molecular mechanisms by which IL-10 suppresses APC function.

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