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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Pillar[5]arene based supramolecular prodrug micelles with pH induced aggregate behavior for intracellular drug
Yin Wang1, Jianwei Du, Youxiang Wang
1MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. jinqiao@zju.edu.cn jijian@zju.edu.cn.
Abstract:
A novel type of dual pH-responsive supramolecular prodrug micelles based on host-guest interactions of water-soluble pillar[5]arene (WP5) and methyl viologen functioned doxorubicin (MV-DOX) was prepared. It was found that the prodrug micelles could be aggregated upon acidic condition, which led to enhanced accumulation and better therapy effect.
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