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Attenuation of cisplathin-induced toxic oxidative stress by propofol
Ghazaleh Taheri Moghadam1, Seyed-Mostafa Hosseini-Zijoud2, Tavakol Heidary Shayesteh3
1Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
Background:
Antioxidant effects of propofol (2, 6-diisopropylphenol) were evaluated against cisplatin-induced oxidative stress in rat.
Objectives:
In this experimental study, 20 male rats were equally divided into 4 groups (5 rats each), and were treated by propofol (10 mg/kg/day, IP), or cisplatin (7 mg /kg/day, IP), or both.
Materials And Methods:
Group one was control, while group 2 was given cisplatin (7 mg /kg/day, IP). Animals of the third group received only propofol (10 mg/kg/day, IP). Group 4 was given propofol with cisplatin once per day for 7 days. After treatment, blood urea nitrogen, creatinine levels, and oxidative stress markers such as total thiol groups (TTG), lipid peroxidation (LPO), and total antioxidant capacity (TAC) were measured.
Results:
Oxidative stress induced by cisplatin, was evident by a significant increase in LPO and decrease in TTG and TAC. Propofol recovered cisplatin -induced changes in TAC, TTG and LPO in blood.
Conclusions:
It is concluded that oxidative damage is the mechanism of cisplatin toxicity, which can be recovered by propofol.
