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Hematopoietic SCT in Iranian children 1991-2012

A A Hamidieh1, M Behfar1, A E S Babaki1

  • 1Hematology-Oncology and Stem Cell Transplantation Research Center/Tehran University of Medical Sciences, Tehran, Iran.

Bone Marrow Transplantation
|January 20, 2015
PubMed

Insights

Pediatric hematopoietic stem cell transplantation (HSCT) in Iran shows increasing activity and encouraging survival rates. TBI-free conditioning regimens are exclusively used, offering unique data for future research.

Area of Science:

  • Hematology
  • Pediatric Oncology
  • Immunology

Background:

  • Hematopoietic stem cell transplantation (HSCT) is a critical treatment for various pediatric diseases.
  • Understanding national HSCT activity provides insights into treatment accessibility and outcomes.
  • The use of TBI-free conditioning regimens in pediatric HSCT is an area of ongoing research.

Purpose of the Study:

  • To report the activity and outcomes of pediatric hematopoietic stem cell transplantation (HSCT) in Iran from 1991 to 2012.
  • To analyze the trends, indications, donor sources, and survival rates of pediatric HSCT.
  • To highlight the exclusive use of TBI-free conditioning regimens and their implications.

Main Methods:

  • Retrospective analysis of 1105 pediatric HSCT cases performed between 1991 and 2012.
  • Data collection on patient demographics, diagnoses, donor types, conditioning regimens, and outcomes.
  • Calculation of overall survival (OS) and disease-free survival (DFS) rates.

Main Results:

  • A total of 1105 pediatric HSCTs were performed, with a notable increase in annual activity since 2007.
  • The primary indications were inherited red blood cell disorders (45.88%), leukemias (27.6%), and bone marrow failure syndromes (11.94%).
  • Two-year OS and DFS rates were 74.2% and 66.3%, respectively. Transplant-related mortality (TRM) and relapse were leading causes of death.

Conclusions:

  • Pediatric HSCT activity in Iran has grown significantly, with established survival rates.
  • The exclusive use of TBI-free conditioning regimens in all cases provides valuable data for comparison.
  • Encouraging survival outcomes support further investigation into TBI-free conditioning for pediatric HSCT.

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