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A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
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Deterministic effects after fenestrated endovascular aortic aneurysm repair
Melissa L Kirkwood1, Gary M Arbique2, Jeffrey B Guild2
1Division of Vascular and Endovascular Surgery, Department of Surgery, UT Southwestern Medical Center, Dallas, Tex.
Journal of Vascular Surgery
|January 21, 2015
Summary
Deterministic skin injuries are uncommon after fenestrated endovascular aortic aneurysm repair (FEVAR), even at high radiation doses. Comprehensive examinations found no injuries, suggesting radiation skin effects are multifactorial and not solely dose-dependent.
Area of Science:
- Medical Imaging and Radiation Oncology
- Vascular Surgery
- Patient Safety and Radiation Protection
Background:
- Fenestrated endovascular aortic aneurysm repair (FEVAR) involves high radiation doses, posing a risk for deterministic skin injuries.
- Previous retrospective studies showed no skin injuries despite high peak skin doses (PSDs).
- This study aimed to investigate potential under-reporting of skin injuries in FEVAR procedures.
Purpose of the Study:
- To examine deterministic radiation effects on the skin in FEVAR patients.
- To implement procedural changes to enhance the detection of skin injuries.
- To evaluate the relationship between radiation dose and skin injury incidence.
Main Methods:
- Included FEVAR patients with radiation dose ≥ 5 Gy reference air kerma (RAK).
- Patients underwent daily skin examinations until discharge and follow-ups at 2, 4 weeks, and 3, 6 months.
- Peak skin dose (PSD) distributions were calculated and validated; cumulative doses were considered for patients with multiple procedures.
Main Results:
- 21 FEVAR patients met the inclusion criteria with an average RAK of 7.6 Gy and mean PSD of 4.8 Gy.
- Fifty-two percent of patients had multiple procedures, with a mean RAK of 10.0 Gy and mean PSD of 6.6 Gy.
- No radiation-induced skin injuries (erythema, epilation, necrosis) were observed, despite high radiation doses and cumulative exposure.
Conclusions:
- Deterministic skin injuries appear uncommon after FEVAR, even with substantial radiation exposure.
- Comprehensive postoperative skin examinations and patient questioning did not reveal any radiation-induced injuries.
- Radiation-induced skin injuries are likely multifactorial, with factors beyond just radiation dose influencing their occurrence.
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