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Updated: Apr 18, 2026

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

Targeting T cell metabolism for therapy.

David O'Sullivan¹, Erika L Pearce¹

¹Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Trends in Immunology

|January 21, 2015

Summary

T cell metabolism is crucial for their function and fate. Understanding and manipulating these metabolic pathways offers new therapeutic strategies for cancer, autoimmunity, and inflammation.

Area of Science:

Immunology
Metabolic pathways
Cellular biology

Background:

Metabolism significantly influences T cell biology, differentiation, and fate.
Metabolic alterations are implicated in inflammatory and cancerous conditions.
T cell dysfunction can arise in challenging microenvironments.

Purpose of the Study:

To review emerging principles in T cell metabolism regulation.
To discuss metabolic impacts in inflammation and cancer.
To explore therapeutic manipulation of T cell metabolism.

Main Methods:

Literature review of T cell metabolism.
Analysis of metabolic roles in disease contexts.
Discussion of potential therapeutic interventions.

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Main Results:

Metabolism is a key regulator of T cell function and differentiation.
Inflammation and cancer alter T cell metabolic profiles.
Metabolic targeting can prevent T cell dysfunction.

Conclusions:

Targeting T cell metabolism holds promise for treating human diseases.
Strategies include enhancing adoptive cellular immunotherapies.
Metabolic manipulation can guide T cells toward non-pathogenic phenotypes.