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Effects of bradykinin on PC-12 cell differentiation
M R Kozlowski1, M P Rosser, E Hall
1Department of Screening and Biochemical Research, Bristol-Myers Company, Wallingford, CT 06492-7660.
Peptides
|November 1, 1989
Abstract:
PC-12 cells are used as a model for neuronal differentiation because they assume a neuronal phenotype, including the extension of neurites, when exposed to nerve growth factor (NGF). The present results show that bradykinin (BK) also causes PC-12 cells to extend neurites. In addition, BK potentiates the neurite-extending effect of nerve growth factor (NGF), an action which is attenuated by a BK antagonist. The potentiation of neurite extension produced by the combination of BK and NGF may be mediated at the receptor level, as indicated by an NGF-induced alteration of BK binding.