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Updated: Apr 18, 2026

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Using CellML with OpenCMISS to Simulate Multi-Scale Physiology.

David P Nickerson¹, David Ladd¹, Jagir R Hussan¹

¹Auckland Bioengineering Institute, University of Auckland , Auckland , New Zealand.

Frontiers in Bioengineering and Biotechnology

|January 21, 2015

Summary

This summary is machine-generated.

OpenCMISS integrates CellML models for customizable bioengineering simulations, enhancing multi-scale physiological modeling. This approach simplifies complex computational experiments for researchers, improving reproducibility and interoperability.

Keywords:

CellML OpenCMISS multi-scale physiological model physiome project virtual physiological human

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Area of Science:

Bioengineering
Computational Biology
Multiscale Modeling

Background:

OpenCMISS is an open-source environment for bioengineering problems.
It comprises computational (OpenCMISS-Iron) and visualization (OpenCMISS-Zinc) libraries.
Designed for coupled multi-scale, multi-physics problems in parallel environments.

Purpose of the Study:

To detail the integration of CellML models within OpenCMISS for multi-scale physiological modeling.
To describe the user interface and demonstrate the extensibility and usability of OpenCMISS.
To facilitate customized computational experiments without requiring deep knowledge of OpenCMISS internals.

Main Methods:

Utilizing CellML, an XML format for biophysical models, within OpenCMISS.
Implementing CellML for configuring cellular electrophysiology, material properties, and boundary conditions.
Describing the external interface and providing specific examples of model integration.

Main Results:

Successful integration of CellML models into OpenCMISS for diverse bioengineering applications.
Demonstrated extensibility and usability for the physiological modeling community.
Enabled users to configure complex multi-scale models through a simplified interface.

Conclusions:

OpenCMISS effectively leverages CellML to enhance multi-scale physiological modeling.
Future extensions include integrating other standards like FieldML, SED-ML, and BioSignalML.
Exploration of integrating accelerator code (GPU, FPGA) generated from CellML models is planned.