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Updated: Apr 18, 2026
28:13
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
34.4K
[Interventional stroke prophylaxis : endocardial and epicardial left atrial appendage closure]
A Rillig1, C H Heeger, K H Kuck
1Abteilung für Kardiologie, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Deutschland, arillig5@yahoo.de.
Herz
|January 22, 2015
Summary
Atrial fibrillation (AF) poses a significant stroke risk. Left atrial appendage (LAA) closure devices offer an alternative to anticoagulation, aiming to reduce stroke risk while minimizing bleeding complications.
Area of Science:
- Cardiology
- Medical Devices
- Stroke Prevention
Context:
- Atrial fibrillation (AF) is a leading cause of ischemic stroke.
- Oral anticoagulation reduces stroke risk but increases bleeding risk.
- Left atrial appendage (LAA) thrombi are found in over 90% of AF patients.
Purpose:
- To review current endocardial and epicardial LAA closure devices.
- To assess indications, management, and outcomes of LAA closure.
- To compare LAA closure devices as an alternative to oral anticoagulation.
Summary:
- LAA closure devices, including endocardial (WATCHMAN™, AMPLATZER™) and epicardial (LARIAT™) options, are emerging alternatives to oral anticoagulation for stroke prevention in AF.
- These devices target thrombi within the LAA, a common source of emboli in AF patients.
- The review evaluates the clinical evidence for these devices, focusing on their efficacy and safety profiles.
Impact:
- Provides a comprehensive overview of LAA closure technologies for clinicians.
- Informs treatment decisions for stroke risk reduction in AF patients.
- Highlights the evolving landscape of interventional cardiology for AF management.
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