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Updated: Apr 18, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

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[Interventional stroke prophylaxis : endocardial and epicardial left atrial appendage closure]

A Rillig1, C H Heeger, K H Kuck

  • 1Abteilung für Kardiologie, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Deutschland, arillig5@yahoo.de.

Herz
|January 22, 2015
PubMed

Insights

Atrial fibrillation (AF) poses a significant stroke risk. Left atrial appendage (LAA) closure devices offer an alternative to anticoagulation, aiming to reduce stroke risk while minimizing bleeding complications.

Area of Science:

  • Cardiology
  • Medical Devices
  • Stroke Prevention

Context:

  • Atrial fibrillation (AF) is a leading cause of ischemic stroke.
  • Oral anticoagulation reduces stroke risk but increases bleeding risk.
  • Left atrial appendage (LAA) thrombi are found in over 90% of AF patients.

Purpose:

  • To review current endocardial and epicardial LAA closure devices.
  • To assess indications, management, and outcomes of LAA closure.
  • To compare LAA closure devices as an alternative to oral anticoagulation.

Summary:

  • LAA closure devices, including endocardial (WATCHMAN™, AMPLATZER™) and epicardial (LARIAT™) options, are emerging alternatives to oral anticoagulation for stroke prevention in AF.
  • These devices target thrombi within the LAA, a common source of emboli in AF patients.
  • The review evaluates the clinical evidence for these devices, focusing on their efficacy and safety profiles.

Impact:

  • Provides a comprehensive overview of LAA closure technologies for clinicians.
  • Informs treatment decisions for stroke risk reduction in AF patients.
  • Highlights the evolving landscape of interventional cardiology for AF management.

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