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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
351
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
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Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

310
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Related Experiment Video

Updated: Apr 18, 2026

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
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[Obesity and primiparity: Risky delivery?].

A L Dubourdeau1, A Berdin1, M Mangin1

  • 1Pôle mère-femme, CHRU Jean-Minjoz, boulevard Fleming, 25000 Besançon, France.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|January 22, 2015
PubMed
Summary

Obese primiparous women face higher risks of labor induction, postpartum hemorrhage, and cesarean delivery. Their newborns have significantly higher birth weights and increased rates of macrosomia, highlighting the need for specialized care.

Keywords:
AccouchementComplications obstétricalesDeliveryObesityObstetrical complicationsObésitéPrimiparityPrimiparité

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Reproductive Health

Context:

  • Primiparous women represent a significant obstetric population.
  • Maternal obesity (Body Mass Index [BMI] ≥30) is a growing concern in pregnancy.
  • Understanding materno-foetal complication risks in obese primiparous women is crucial for clinical management.

Purpose:

  • To evaluate the association between maternal obesity and adverse materno-foetal outcomes in primiparous women.
  • To compare complication rates between obese (BMI ≥30) and non-obese (BMI <30) primiparous women.

Summary:

  • A retrospective study analyzed 1636 primiparous women, with 132 classified as obese.
  • Obese women experienced significantly higher rates of labor induction, prolonged pregnancy, postpartum hemorrhage, and cesarean delivery (P<0.001).
  • Mean birth weight and macrosomia rates were significantly elevated in newborns of obese mothers (16.7% vs 5.2%, P<0.001).

Impact:

  • Maternal obesity is a significant risk factor for obstetrical complications in primiparous women.
  • Obese primiparous patients require specialized management upon arrival at the labor ward.
  • Proactive management strategies are essential to improve maternal and neonatal outcomes in this high-risk group.