Related Experiment Video
Updated: Dec 27, 2025
07:41
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
Published on: July 12, 2024
3.3K
A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery
Shayan F Lahiji1, Manita Dangol1, Hyungil Jung1
1Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-749, Korea.
Scientific Reports
|January 22, 2015
Summary
Microlancer, a novel micropillar system, improves dissolving microneedle (DMN) drug delivery. This system achieves high drug delivery efficiency across diverse skin types, overcoming limitations of current patch-based DMNs.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Dissolving microneedles (DMNs) offer minimally invasive drug delivery.
- Current DMN patches face challenges with skin elasticity and hair, leading to incomplete insertion and low drug delivery efficiency.
Purpose of the Study:
- To introduce "Microlancer", a novel micropillar-based system for self-administration of DMNs.
- To enhance drug delivery efficiency and overcome limitations of existing DMN patch technologies.
Main Methods:
- Development of a novel micropillar-based system named "Microlancer".
- Utilizing Microlancer for self-administration of DMNs.
- Evaluation of drug delivery efficiency across varied skin types and hair densities.
Main Results:
- Microlancer achieved a high drug delivery efficiency of 97 ± 2%.
- The system demonstrated consistent performance regardless of skin elasticity or hair presence.
- Drug delivery was accomplished in less than one second.
Conclusions:
- The Microlancer system represents a significant advancement in DMN drug delivery.
- It offers a reliable and efficient method for self-administration, improving patient outcomes.
- This technology addresses key limitations of current DMN patch applications.
Related Concept Videos
01:09In Vitro Drug Dissolution: Compendial Testing Models II
163
Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
163
01:22Drug Delivery: Miscellaneous Routes
673
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
673
01:16Drug Delivery: Overview
660
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
660
01:15Non-Oral Extravascular Drug Absorption Routes
444
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
444
01:18Drug Delivery: Enteral Route
1.4K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.4K
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.5K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.5K