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Updated: Apr 18, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
Function of CD147 in atherosclerosis and atherothrombosis
Cuiping Wang1, Rong Jin, Xiaolei Zhu
1Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu province, People's Republic of China, 212001.
Abstract:
CD147, a member of the immunoglobulin super family, is a well-known potent inducer of extracellular matrix metalloproteinases. Studies show that CD147 is upregulated in inflammatory diseases. Atherosclerosis is a chronic inflammatory disease of the artery wall. Further understanding of the functions of CD147 in atherosclerosis and atherothrombosis may provide a new strategy for preventing and treating cardiovascular disease. In this review, we discuss how CD147 contributes to atherosclerosis and atherothrombosis.
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