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Updated: Apr 18, 2026

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

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A multicentered prospective analysis of diagnosis, risk factors, and outcomes associated with pediatric

Sameer Gupta1, Brian M Boville, Rachel Blanton

  • 11University of Minnesota Masonic Children's Hospital, Minneapolis, MN. 2Helen DeVos Children's Hospital, Grand Rapids, MI. 3Children's Hospital Association, Alexandria, VA. 4Akron Children's Hospital, Akron, OH.

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|January 22, 2015
PubMed

Insights

Pediatric ventilator-associated pneumonia (VAP) is common in children requiring mechanical ventilation. VAP increases intensive care unit (ICU) length of stay, ventilation duration, and mortality risk.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Respiratory medicine

Background:

  • Ventilator-associated pneumonia (VAP) is a significant concern in pediatric intensive care units (PICUs).
  • Understanding the prevalence, risk factors, and outcomes of VAP in children is crucial for improving patient care.

Purpose of the Study:

  • To assess the prevalence, risk factors, and outcomes associated with pediatric ventilator-associated pneumonia.
  • To evaluate diagnostic criteria for pediatric VAP.

Main Methods:

  • Multicentered prospective observational cohort study.
  • Involved mechanically ventilated patients under 18 years old across children's hospitals in the United States.

Main Results:

  • The prevalence of pediatric VAP was 5.2% (7.1 per 1,000 ventilator days).
  • VAP was associated with significantly longer ICU length of stay and mechanical ventilation duration.
  • Patients with VAP had a nearly threefold increased risk of mortality.
  • Independent risk factors included reintubation and part-time ventilation.

Conclusions:

  • Pediatric VAP is a common and serious complication in mechanically ventilated children.
  • VAP significantly increases morbidity and mortality in this vulnerable population.
  • Identifying and mitigating risk factors for VAP is essential in pediatric critical care.
Abstract

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