Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

890
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
890
Appendicitis01:19

Appendicitis

3
Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
3
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

4.1K
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
4.1K
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

1.0K
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of socioeconomic deprivation on colorectal cancer outcomes; a retrospective regional cohort study.

International journal of colorectal disease·2026
Same author

Minimal Clinically Important Difference (MCID) of the EOSQ-24 Questionnaire.

Journal of pediatric orthopedics·2026
Same author

VEPTR treatment of early onset scoliosis in children without rib abnormalities: 10-year follow-up from a prospective multicenter study.

Spine deformity·2026
Same author

Beyond the nerve: Understanding cortical contributions to post-paralytic facial synkinesis.

Behavioural brain research·2026
Same author

An essential medicines list in Ireland: A qualitative interview study of interest-holders.

Health policy (Amsterdam, Netherlands)·2026
Same author

Gabapentinoids and unexplained death in general practice: Case series and feasibility study arising from a critical incident.

The European journal of general practice·2026

Related Experiment Video

Updated: Apr 18, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.9K

A model predicting perforation and complications in paediatric appendicectomy.

Obinna Obinwa1, Colin Peirce, Michael Cassidy

  • 1Department of Surgery, Portiuncula Hospital, Ballinasloe, County Galway, Ireland, obinnaobinwa@rcsi.ie.

International Journal of Colorectal Disease
|January 23, 2015
PubMed
Summary

Early detection of advanced appendicitis is crucial. Preoperative fever, anorexia, and rebound tenderness, along with a high white blood cell (WBC) count, are key indicators for advanced appendicitis in children.

More Related Videos

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
08:26

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

2.1K
Technical Detail for Robot Assisted Pancreaticoduodenectomy
14:45

Technical Detail for Robot Assisted Pancreaticoduodenectomy

Published on: September 28, 2019

15.8K

Related Experiment Videos

Last Updated: Apr 18, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.9K
Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
08:26

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

2.1K
Technical Detail for Robot Assisted Pancreaticoduodenectomy
14:45

Technical Detail for Robot Assisted Pancreaticoduodenectomy

Published on: September 28, 2019

15.8K

Area of Science:

  • Pediatric Surgery
  • Clinical Diagnostics
  • Medical Research

Background:

  • Appendicitis is a common surgical emergency in children.
  • Early and accurate diagnosis of advanced appendicitis (perforation, mass, abscess) is critical to prevent complications.
  • Simple clinical measurements can aid in early detection.

Purpose of the Study:

  • To evaluate the diagnostic value of simple clinical measurements for early detection of advanced appendicitis in pediatric patients.
  • To identify predictors of advanced appendicitis and associated postoperative complications.

Main Methods:

  • Retrospective analysis of 1037 pediatric appendectomies over 14 years.
  • Evaluation of preoperative symptoms, signs, laboratory results, and intra-operative findings.
  • Use of Receiver Operating Characteristic (ROC) curves and multivariate logistic regression to determine predictor accuracy.

Main Results:

  • Advanced appendicitis occurred in 11.9% of cases (8.5% perforation, 3.4% abscess).
  • Preoperative temperature ≥37.5 °C was the most discriminatory factor for advanced appendicitis.
  • Other significant predictors included WBC count ≥15,100/μL, anorexia, and rebound tenderness.
  • Postoperative complications (7.1%) were associated with fever and advanced appendicitis.

Conclusions:

  • While individual clinical predictors lack perfect accuracy, preoperative pyrexia is strongly linked to advanced appendicitis.
  • Fever is also associated with increased risk of postoperative complications.
  • Preoperative fever may indicate the need for prompt antibiotic treatment, imaging, and surgical intervention.