Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Study Designs in Epidemiology01:20

Study Designs in Epidemiology

1.6K
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
1.6K
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

229
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
229
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

575
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
575
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

398
Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to subjects...
398
Clinical Trials: Overview01:11

Clinical Trials: Overview

5.5K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.5K
Randomized Experiments01:13

Randomized Experiments

9.4K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
9.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased Risk of Myocardial Infarction and Stroke Among Multiracial Asian and Pacific Islander Adults With Diabetes: Evidence From Electronic Health Records.

Journal of the American Heart Association·2026
Same author

Analysis of Plasma Extracellular Vesicles in Normal-Weight and Overweight Type 2 Diabetes Mellitus Using Multimodal SERS and RNA-Seq.

bioRxiv : the preprint server for biology·2026
Same author

A High-Fiber, Plant-Based Diet in Myeloma Precursor Disorders: Results from the NUTRIVENTION Clinical Trial and Preclinical Vk*MYC Model.

Cancer discovery·2025
Same author

Validation of the American Heart Association Predicting Risk of Cardiovascular Disease Events Equations in Diverse Socioeconomic Groups: The All of Us Cohort.

Journal of the American Heart Association·2025
Same author

High Prevalence of Prediabetes Among Asian and Pacific Islander Adolescents With Overweight or Obesity in a Primary Care Population.

Diabetes care·2025
Same author

Heart Disease Mortality in the United States, 1970 to 2022.

Journal of the American Heart Association·2025

Related Experiment Video

Updated: Apr 18, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.5K

A Fully Automated Diabetes Prevention Program, Alive-PD: Program Design and Randomized Controlled Trial Protocol.

Gladys Block1, Kristen Mj Azar, Torin J Block

  • 1NutritionQuest, Inc., Berkeley, CA, United States. gblock@berkeley.edu.

JMIR Research Protocols
|January 23, 2015
PubMed
Summary
This summary is machine-generated.

A new automated, web-based program shows promise for preventing diabetes by improving glycemic control in adults with pre-diabetes. This intervention aims to reduce HbA1c and fasting glucose levels effectively.

Keywords:
blood glucosediabetesinsulin resistanceinternetmetabolic syndromeobesityphysical activityprediabetespreventionworld wide web

More Related Videos

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
07:21

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease

Published on: June 16, 2023

1.7K
A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
04:24

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

Published on: April 19, 2019

12.9K

Related Experiment Videos

Last Updated: Apr 18, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.5K
Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
07:21

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease

Published on: June 16, 2023

1.7K
A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
04:24

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

Published on: April 19, 2019

12.9K

Area of Science:

  • Digital Health
  • Preventive Medicine
  • Clinical Trials

Background:

  • 86 million US adults have pre-diabetes, necessitating scalable and cost-effective interventions.
  • Diabetes prevention requires evidence-based strategies to mitigate long-term health risks.

Purpose of the Study:

  • To develop a fully automated diabetes prevention program.
  • To evaluate the effectiveness of the Alive-PD program in a randomized controlled trial.

Main Methods:

  • Recruited subjects with pre-diabetes for a 1-year randomized trial of the Alive-PD program.
  • Alive-PD is an automated, email/web-based intervention with a mobile app, featuring tailored goal-setting, challenges, and gamification.
  • Participants were randomized to immediate intervention or a 6-month delayed start; outcomes measured included HbA1c and fasting glucose.

Main Results:

  • 340 pre-diabetic subjects were randomized; 164 to intervention and 176 to control.
  • Baseline characteristics: mean age 55, BMI 31.1, 68.5% male, mean fasting glucose 109.9 mg/dL, mean HbA1c 5.6% (SD 0.3).
  • Data collection and analysis are ongoing; hypothesis is significant reduction in glucose and HbA1c for the intervention group.

Conclusions:

  • The randomized trial is expected to provide rigorous evidence on the efficacy of this digital program.
  • The study will assess the program's ability to reduce glycemic markers and prevent progression to diabetes.