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Danazol and hepatic neoplasia: a case report
C Middleton1, G W McCaughan, D M Painter
1A. W. Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
Australian and New Zealand Journal of Medicine
|December 1, 1989
Summary
Danazol, used for endometriosis, can cause liver tumors. This case highlights hepatocellular adenoma in a woman taking danazol for three years.
Area of Science:
- Hepatology
- Endocrinology
- Oncology
Background:
- Hepatic side-effects of danazol are recognized.
- The association between danazol and hepatic tumor development is not well-documented.
Observation:
- A 35-year-old woman with endometriosis was treated with danazol for three years.
- Hepatocellular adenoma was observed in this patient.
Findings:
- This case presents a rare instance of hepatocellular adenoma potentially linked to danazol therapy.
- The findings suggest a possible, though not definitively established, role of danazol in hepatic tumor formation.
Implications:
- Further investigation is warranted to understand the risk of hepatic tumors with danazol use.
- Clinicians should be aware of this potential adverse effect when prescribing danazol, especially for long-term treatment.