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Disseminated strongyloidiasis in Erythrocebus patas
J S Harper1, J M Rice1, W T London1
1The National Institutes of Health, Bethesda, Maryland.
American Journal of Primatology
|January 30, 2020
Summary
Fatal disseminated strongyloidiasis occurred in patas monkeys, a novel finding outside of humans and great apes. These monkeys are a suitable model for studying this severe parasitic infection.
Area of Science:
- Veterinary Pathology
- Parasitology
- Primate Research
Background:
- Disseminated strongyloidiasis is a severe parasitic infection primarily documented in humans and great apes.
- The hyperinfective form of Strongyloides poses significant health risks.
Purpose of the Study:
- To report the first cases of fatal disseminated strongyloidiasis in Erythrocebus patas (patas monkeys).
- To evaluate the suitability of E. patas as a model for studying disseminated strongyloidiasis.
Main Methods:
- Necropsy of five fatal cases of disseminated strongyloidiasis in E. patas.
- Histopathological examination of affected tissues to identify Strongyloides larvae.
Main Results:
- Five patas monkeys housed in an indoor research facility died from disseminated strongyloidiasis.
- Key findings included severe pulmonary hemorrhage, duodenitis, and proximal colitis with larvae present in tissues.
- This represents the first report of fatal hyperinfective strongyloides infection in this species.
Conclusions:
- Erythrocebus patas can develop fatal disseminated strongyloidiasis.
- Patas monkeys serve as a viable and available model for research into disseminated strongyloidiasis.
