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3D printed microfluidic devices with integrated valves.

Chad I Rogers1, Kamran Qaderi2, Adam T Woolley1

  • 1Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, USA.

Biomicrofluidics
|January 23, 2015
PubMed
Summary
This summary is machine-generated.

Researchers developed 3D printed microfluidic devices with integrated membrane valves using stereolithography. This low-cost method achieved high yield for precise microchannels and reliable valve function up to 800 actuations.

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Area of Science:

  • * Microfluidics
  • * 3D printing
  • * Materials science

Background:

  • * Microfluidic devices are essential for various lab-on-a-chip applications.
  • * Traditional fabrication methods can be expensive and time-consuming.
  • * Development of integrated valves is crucial for advanced microfluidic control.

Purpose of the Study:

  • * To demonstrate the fabrication of 3D printed microfluidic devices with integrated membrane valves.
  • * To assess the performance and reliability of these 3D printed valves.
  • * To utilize a low-cost, accessible 3D printing technology for microfluidic applications.

Main Methods:

  • * Employed stereolithographic 3D printing with a custom resin formulation for low protein adsorption.
  • * Fabricated horizontal and vertical microfluidic channels with precise dimensions.
  • * Designed and integrated membrane-based valves using a single build layer.

Main Results:

  • * Achieved 100% yield in printing microfluidic channels as small as 350 μm wide and 250 μm tall.
  • * Successfully fabricated vertical channels with 350 μm designed diameters (210 μm actual).
  • * Demonstrated reliable valve operation, with opening pressure matching control pressure, for up to 800 actuations.

Conclusions:

  • * Stereolithographic 3D printing is a viable and cost-effective method for fabricating microfluidic devices with integrated valves.
  • * The developed devices and valves show promise for applications requiring precise fluid control.
  • * The custom resin formulation minimizes protein adsorption, enhancing device utility.