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CD137 stimulation enhances the vaccinal effect of anti-tumor antibodies

Roch Houot1, Holbrook Kohrt2

  • 1CHU Rennes; Service Hématologie Clinique ; Rennes, France ; INSERM ; Rennes, France.

Oncoimmunology
|January 23, 2015
PubMed

Some evidence suggests that monoclonal antibodies (mAb) can induce an adaptive immune response against tumor cells ("vaccinal effect"). Recently, we have shown that an anti-CD137 mAb can enhance the "vaccinal effect" of an anti-tumor mAb (cetuximab), thereby transforming a passive, monoclonal, short-term immunotherapy into an active, polyclonal, long-lasting immune response.

Keywords:
ADCC, antibody-dependent cellular cytotoxicityAg, antigensCDC, complement-dependent cytotoxicityCRC, colorectal cancerDC, dendritic cellsFcR, Fc receptorHN, head and neckMHC, major histocompatibility complexNK, natural killerTCR, T cell receptorantibody-dependent cell mediated cytotoxicity (ADCC)immunotherapymAb, monoclonal antibodiesmonoclonal antibodynatural killer cells

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