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Two in one: improving synthetic long peptide vaccines by combining antigen and adjuvant in one molecule
Gijs G Zom1, Dmitri V Filippov2, Gijsbert A van der Marel2
1Department of Immunohematology and Blood Transfusion; Leiden University Medical Center ; Leiden, The Netherlands.
Abstract:
Aiming to increase the potency of synthetic long peptide (SLP)-based cancer vaccines, the Toll-like receptor 2 (TLR2) ligand Pam3CSK4 was conjugated in a chemically defined fashion to SLPs harbouring both cytotoxic T lymphocyte (CTL) and T helper epitopes. We recently showed that these SLP-conjugates induce strong antitumor immunity in murine cancer models.
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