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Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

2
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
2
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.6K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.6K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

941
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
941
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

3
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
3
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

4
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
4
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

3
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
3

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Related Experiment Video

Updated: Apr 18, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

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Pancreatic panniculitis.

Sam Shiyao Yang1, Gwyneth Shook Ting Soon, Derrick Chen-Wee Aw

  • 1Department of General Medicine, University Medicine Cluster, National University Health System. samsyyang@gmail.com.

Dermatology Online Journal
|January 23, 2015
PubMed
Summary
This summary is machine-generated.

A rare rash on the legs, identified as pancreatic panniculitis, can signal an underlying pancreatic cancer. This case highlights how skin conditions may indicate serious internal diseases.

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A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
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Last Updated: Apr 18, 2026

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A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
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Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Pancreatic adenocarcinoma is a challenging cancer with often late diagnosis.
  • Cutaneous manifestations can sometimes precede the diagnosis of internal malignancies.

Observation:

  • A patient presented with a lower leg rash.
  • Skin biopsy revealed lobular panniculitis and "ghost" adipocytes.

Findings:

  • The skin findings were consistent with pancreatic panniculitis.
  • This indicated an underlying pancreatic adenocarcinoma.

Implications:

  • This case underscores the importance of investigating dermatological symptoms.
  • Early recognition of skin signs may lead to earlier cancer diagnosis and treatment.