Impact of mineralocorticoid receptor polymorphisms on urinary electrolyte excretion with and without diuretic drugs
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Updated: Apr 18, 2026

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
Published on: September 1, 2015
Nawar Dalila1, Jürgen Brockmöller, Mladen Vassilev Tzvetkov
1Institute of Clinical Pharmacology, University Medical Center Göttingen, Göttingen, Germany.
Aim:
Polymorphisms in the mineralocorticoid receptor may affect urinary sodium and potassium excretion. We investigated polymorphisms in the MR gene in relation to urinary electrolyte excretion in two separate studies.
Patients & Methods:
The genotype-phenotype association was studied in healthy volunteers after single doses of bumetanide, furosemide, torsemide, hydrochlorothiazide, triamterene and after NaCl restriction.
Results:
High potassium excretion under all conditions except torsemide, and high NaCl excretion after bumetanide and furosemide were associated with the A allele of the intron-3 polymorphism (rs3857080). This polymorphism explained 5-10% of the functional variation and in vitro, rs3857080 affected DNA binding of the transcription factor LHX4.
Conclusion:
rs3857080 may be a promising new candidate for research in cardiac and renal disorders and on antialdosteronergic drugs like spironolactone.
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