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Olaparib: first global approval

Emma D Deeks1

  • 1Springer, Private Bag 65901, Mairangi Bay 0754, Auckland, New Zealand, dru@adis.com.

Drugs
|January 25, 2015
PubMed

Insights

Olaparib, a poly (ADP-ribose) polymerase inhibitor, is approved for BRCA-positive ovarian cancer. Further trials are exploring its efficacy in breast, gastric, pancreatic, and other solid tumors.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Olaparib (Lynparza™) is an oral poly (ADP-ribose) polymerase (PARP) inhibitor.
  • It is developed by AstraZeneca for treating solid tumors, with a primary focus on BRCA mutation-positive ovarian cancer.

Purpose of the Study:

  • To summarize the development milestones of olaparib.
  • To highlight its first approval for ovarian cancer treatment.

Main Methods:

  • Review of olaparib's development pathway.
  • Summary of clinical trial phases and global reach.

Main Results:

  • Olaparib capsule formulation approved in the EU and USA for BRCA-positive ovarian cancer.
  • Tablet formulation is in global phase III trials across multiple countries.
  • Phase III trials are ongoing/planned for breast, gastric, and pancreatic cancers.
  • Phase I/II investigations are underway for prostate cancer, non-small cell lung cancer, Ewing's sarcoma, and advanced cancers.

Conclusions:

  • Olaparib represents a significant advancement in targeted cancer therapy.
  • Its development trajectory shows potential for broad application in various solid tumors.

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