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Updated: Apr 18, 2026
Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
A new three-dimensional measurement in evaluating the cranial asymmetry caused by craniosynostosis
Hongyu Yin1, Xue Dong1,2, Bin Yang3
1Department of Maxillofacial Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 33, Badachu Road, Shijingshan District, Beijing, 100144, China.
Purpose:
To present a modified cranial vault asymmetry index, evaluate it by measuring the asymmetry of the skull shape with craniosynostosis and by assessing the surgical outcome quantitatively, compare it with traditional cranial vault asymmetry index (CVAI) and discuss its advantages and shortcomings.
Methods:
Based on the traditional CVAI, anterior cranial vault asymmetry index (ACVAI) and posterior cranial vault asymmetry index (PCVAI) were proposed to evaluate surgical outcomes. We measured CVAI, ACVAI and PCVAI on the reconstructed three-dimensional computed tomography images to analyze the degree of the malformation and assess the surgical outcomes. The new method was compared with the traditional one, and statistical analysis was performed.
Results:
Using Wilcoxon Rank Sum Test, preoperative ACVAI compared to postoperative one is statistically significant (p = 0.018), whereas, the p value for CVAI is 0.128 > 0.05.
Conclusions:
The ACVAI and PCVAI as modified can better describe the degree of cranial vault asymmetry compared with CVAI. It is also a more reliable index to assess the surgical outcomes quantitatively.
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