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Related Experiment Video

Updated: Apr 18, 2026

Investigating the Three-dimensional Flow Separation Induced by a Model Vocal Fold Polyp
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Characterizing liquid redistribution in a biphasic vibrating vocal fold using finite element analysis.

Anton A Kvit1, Erin E Devine1, Jack J Jiang1

  • 1Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.

Journal of Voice : Official Journal of the Voice Foundation
|January 27, 2015
PubMed
Summary

This study modeled vocal fold vibration, revealing liquid accumulation at the midline and increased stress. These findings may explain benign lesion formation mechanisms.

Keywords:
Benign lesionsBiomechanicsFinite element analysisVocal folds

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Area of Science:

  • Biomechanics
  • Vocal fold physiology
  • Computational modeling

Background:

  • Vocal fold tissue is biphasic, comprising a solid matrix and interstitial fluid.
  • Liquid-solid interactions influence vocal fold material properties and stress response.
  • Benign lesions often form near the anterior-posterior midline of vocal folds.

Purpose of the Study:

  • To model liquid movement during vocal fold vibration.
  • To estimate liquid accumulation and stress at the midline.
  • To investigate factors contributing to benign lesion formation.

Main Methods:

  • Developed a 3D biphasic finite element model of a vocal fold.
  • Used COMSOL Multiphysics to simulate vibration-induced liquid velocity, pore pressure, and von Mises stress.
  • Applied direct load pressures to simulate vibration and analyzed frequency-stress and amplitude-stress relationships.

Main Results:

  • Observed liquid movement towards the midline and in the inferior-superior direction during vibration.
  • Found higher pore pressure and von Mises stress in the midline region post-vibration.
  • Established a linear relationship between amplitude and pore pressure, and a nonlinear relationship between frequency and pore pressure.

Conclusions:

  • This is the first biphasic finite element model with realistic geometry to characterize vibration-induced liquid movement.
  • Significant liquid accumulation occurs at the midline, though its role needs further study.
  • Investigating these mechanical factors could illuminate benign vocal fold lesion formation mechanisms.