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[Fatal adenovirus pneumonia].
Revista Chilena De Pediatria
|May 1, 1989
Summary
Adenoviruses caused fatal acute lower respiratory infections in 25 infants, often linked to malnutrition and hospital-acquired infections. Necrotizing bronchiolitis was a common finding in these severe pediatric adenovirus cases.
Area of Science:
- Pediatric Pathology
- Virology
- Respiratory Medicine
Context:
- Adenoviruses are common causes of respiratory illness in children.
- Severe outcomes, including fatalities, can occur in young children with adenoviral respiratory infections.
Purpose:
- To report on the clinical and histopathological features of 25 infants who died from acute lower respiratory tract infections attributed to adenoviruses.
- To document the diagnostic findings and associated factors in fatal pediatric adenovirus cases.
Summary:
- The study examined 25 infants with fatal acute lower respiratory tract infections, diagnosed via intranuclear inclusions in pulmonary lesions.
- Necrotizing bronchiolitis was present in 96% of cases. Most infants were under one year old and had malnutrition.
- A significant proportion (68%) of infections were nosocomial, and antimicrobial treatments were unsuccessful in 96% of patients.
Impact:
- Highlights the severe potential of adenovirus infections in vulnerable infants.
- Underscores the importance of considering nosocomial infections and underlying conditions like malnutrition in severe pediatric respiratory cases.
- Suggests limitations of antimicrobial therapy for severe adenoviral respiratory disease in infants.