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Phaeohyphomycosis due to Phialophora richardsiae
The Australasian Journal of Dermatology
|January 1, 1989
Summary
This study reports a rare fungal infection, phaeohyphomycosis, in an immunosuppressed patient. Itraconazole effectively treated the infection, resolving lesions without adverse effects.
Area of Science:
- Mycology
- Dermatology
- Infectious Diseases
Background:
- Phaeohyphomycosis is a rare fungal infection caused by dematiaceous fungi.
- It primarily affects immunosuppressed individuals.
Observation:
- A 64-year-old boat-builder on immunosuppressive therapy (prednisone, azathioprine) presented with multiple cutaneous nodules.
- Histopathology revealed fungal elements (spores and hyphae) and a mixed inflammatory infiltrate.
- Cultures identified Phialophora richardsiae and Exophiala jeanselmei.
Findings:
- Initial treatment with fluorocytosine was ineffective due to fungal resistance.
- Subsequent treatment with itraconazole, a potent triazole, led to complete resolution of lesions.
- The patient experienced no adverse clinical or biochemical effects during itraconazole therapy.
Implications:
- This case highlights the importance of accurate fungal identification and susceptibility testing in managing phaeohyphomycosis.
- Itraconazole demonstrates efficacy and a favorable safety profile for treating this uncommon infection.
- Further research into optimal antifungal strategies for phaeohyphomycosis in immunocompromised patients is warranted.