Related Experiment Video
Updated: Apr 18, 2026

Author Spotlight: Dermatopathology and the Treatment of Sexually Transmitted Diseases
Published on: November 8, 2024
Photoletter to the editor: Acquired idiopathic generalized anhidrosis
1Department Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Friedrichstrasse 41, 01067 Dresden, Germany.
Abstract:
Anhidrosis is a failure in sweat production in response to physiological thermal or chemical stimuli. Acquired idiopathic generalized anhidrosis is a rare disorder without sweat gland pathology and without neurologic symptoms. Most cases have been reported from Far East. We report a case of a 58-year-old Caucasian male who suffered from heat intolerance, heat-induced cutaneous burning and failed to sweat even in sauna for five years. A skin biopsy disclosed no pathologies. He had no neurologic disorders. The diagnosis of acquired idiopathic generalized anhidrosis was confirmed and treatment with methylprednisolone initiated. This led to improvement of heat tolerance, remission of burning and partial remission of sweating.
Related Concept Videos
Accessory Structures of the Skin: Sweat Glands
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
Thermosensation
Somatosensation
Assessing Body Temperature - Axilla
Step 1: Perform hand hygiene and put on clean gloves to maintain infection control and prevent cross-contamination.
Step 2: Prepare the patient by explaining the procedure to ensure understanding and cooperation. Ensure privacy, expose the axilla, and inform the patient that minimal movement is crucial for an accurate reading.
Step 3: Adjust the patient’s clothing to expose only the axilla. It minimizes...
Allergic Reactions
Responses to Heat and Cold Stress

